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2018良性前列腺增生患者前列腺体积与最大尿流率、IPSS的相关性的综述

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发表于 2018-8-18 21:38:36 | 显示全部楼层 |阅读模式
 【摘要】目的探讨良性前列腺增生(BPH)患者前列腺体积与最大尿流率、国际前列腺症状评分(IPSS)之间的相关性。方法选择2013年4月至2014年5月收治的BPH患者共150例作为研究对象,均行尿动力学检查、经直肠超声检查及IPSS,根据Qmax结果的不同分为A组(Qmax10 ml/s)91例、B组(Qmax=11~15 ml/s)38例、C组(Qmax15 ml/s)21例。结果150例患者Qmax平均为(8.12.5)ml/s,TPV平 本文由WwW. 提供,毕业论文 网专业代写教育教学论文和毕业论文以及发表论文服务,欢迎光临均为(46.713.4)ml,TZV平均为(2897.2)ml,IPSS评分平均为(23.56.4)分。B组TPV、TZV、IPSS评分低于A组,但比较差异无统计学意义(P0.05),而C组TPV、TZV、IPSS评分明显低于A组,比较差异有统计学意义(P0.01);C组TPV、TZV、IPSS评分低于B组,但比较差异无统计学意义(P0.05)。经Spearman相关性分析结果显示,Qmax与TPV、TZV呈显著负相关(P0.05),IPSS评分与TPV、TZV呈显著正相关(P0.05),Qmax与IPSS评分呈显著负相关(P0.05)。结论在良性前列腺增生患者中,前列腺体积与最大尿流率、IPSS明显相关,前列腺体积越大,患者最大尿流率越低,下尿路症状越严重。
  【关键词】良性前列腺增生;前列腺体积;最大尿流率;国际前列腺症状评分
  中图分类号:R697+.32 文献标识码:ADOI:10.3969/j.issn.10031383.2015.03.005
  Study of correlation of prostate volume with maximal urinary flow rate
  and IPSS in patients with benign prostatic hyperplasia
  WU Qingguo,HUANG Xianghua,QIN Bin,LI Changzan,JI Hanchu,
  LIANG Yangbing,LIANG Yiwen,ZHANG Jiange
  (Department of Urology,The Eighth Affiliated Hospital of Guangxi Medical
  University―Peoples Hospital of Guigang,Guigang 537100,Guangxi,China)
  【Abstract】ObjectiveTo investigate the correlation of prostate volume with maximal urinary flow rate and international prostate symptom score(IPSS) in benign prostatic hyperplasia (BPH) patients.Methods150 cases of benign prostatic hyperplasia admitted to hospital from April,2013 to May,2014 were selected as study objects.All cases were given urodynamic examination,transrectal ultrasound and IPSS.According to Qmax,all patients were divided into group A(Qmax10 ml/s,91 cases),Group B (Qmax=11~15 ml/s,38 cases) and group C(Qmax15 ml/s,21 cases).Results Average Qmax of all patients was(8.12.5)ml/s,average TPV was(46.713.4)ml,average TZV was(28.97.2)ml,and average IPSS was(23.56.4)points.The TPV,TZV and IPSS of the group B were lower than those of the group A,but there was no statistically significant difference between two groups(P0.05).The TPV,TZV and IPSS of the group C were also significantly lower than those of the group A,and difference was statistically significant(P0.01).The TPV,TZV and IPSS of the group C were lower than those of the group B,but there was no statistically significant difference between two groups(P0.05).Spearman correlation analysis showed that Qmax had significantly negative correlation with TPV and TZV(P0.05),while IPSS had significantly positive correlation with TPV and TZV (P0.05).And the Qmax had significantly positive correlation with IPSS (P0.05).ConclusionThe prostate volume is associated with Qmax and IPSS in patients with benign prostatic hyperplasia.The greater the prostate volume,the lower the Qmax and the more severe the lower urinary tract symptoms. 【Key words】benign prostatic hyperplasia;prostate volume;maximal urinary flow rate;international prostate symptom score
  良性前列腺增生(benign prostatic hyperplasia,BPH)是泌尿外科老年男性最为常见的疾病,病理性增大的前列腺腺体对患者尿道通畅造成不同程度的影响,从而导致排尿困难、尿频、泌尿系统感染、血尿等一系列症状的产生[1]。对BPH患者病情评估及治疗方式选择往往需要结合患者临床症状、尿动力学检查及超声影像学等进行综合判断。本研究对患者前列腺体积(prostate volume,PV)与最大尿流率(maximal urinary flow rate,Qmax)、国际前列腺症状评分(international prostate symptom score,IPSS)间的相关性进行探讨,进一步了解BPH临床病理变化特点,为其早期诊治提供一定的参考。
  1资料与方法1.1一般资料选择2013年4月至2014年5月我院收治的BPH患者共150例,年龄52~84岁,平均(64.87.2)岁;病程5个月~13年,平均(4.11.6)年。患者术前主诉不同程度尿频、排尿不尽、尿细线、夜尿频多等,其中28例合并有尿潴留现象。生活质量评估(quality of life assessment,QOL)为3~6分,平均(5.10.6)分。所有病例均行前列腺特异性抗体(prostate specific antigen,PSA)检查,结合临床症状、直肠指检、常规尿道膀胱镜等检查确诊,且排除尿道狭窄、前列腺癌的可能。IPSS根据医生接诊时参照国际前列腺症状评分表询问患者获得。
  1.2检查方法
  1.2.1Qmax的检查所有患者均于治疗前2~3 d及治疗后1个月进行尿动力学检测。仪器采用四川成都维信公司的Nidoc970A尿流动力学分析仪,留置尿管患者在拔除尿管2~3小时进行测定。根据不同的检查项目取相应的体位,先嘱咐患者自行排尿,测定自由尿流率。然后常规消毒铺巾,经尿道置入F8膀胱双腔测压导管并固定,测膀胱残余尿量,再经肛门置入F12直肠测压管,将仪器调零和传感器校正,并确认测压感与分析仪的妥善连接。将生理盐水以50 ml/min的恒速向膀胱内灌注,行压力尿流率测定,记录患者Qmax。并根据Qma
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